abstract：:Iron oxide nanoparticles (ION) have attracted much attention because of their particular physico-chemical properties, including superparamagnetism. These features make them suitable for many purposes and several interesting biomedical applications, such as to increase contrast in magnetic resonance imaging (MRI), as d...

journal_title：Advances in experimental medicine and biology

authors： Laffon B,Fernández-Bertólez N,Costa C,Brandão F,Teixeira JP,Pásaro E,Valdiglesias V

更新日期：2018-01-01 00:00:00

abstract：:Nanomaterials are invading our environment due to their increasing use in a very broad range of sectors making human exposure foreseeable during the life cycle of these materials. Inhalation is one of the most frequent routes of exposure in case of unintentional exposure and the small size of nanomaterials allows them...

journal_title：Advances in experimental medicine and biology

authors： Puisney C,Baeza-Squiban A,Boland S

更新日期：2018-01-01 00:00:00

abstract：:Food allergy is a common condition in children and adolescent, remitting with time. Few clinical studies have emphasized the link between food allergies and psychosocial conditions, suggesting a profound impact of atopic diseases on the development of attention-deficit hyperactivity disorder (ADHD) in children. The ob...

journal_title：Advances in experimental medicine and biology

authors： Miłosz M,Demkow U,Wolańczyk T

更新日期：2018-01-01 00:00:00

abstract：:Freeze-drying is a popular method to prepare pharmaceutical formulations containing structurally complex active ingredients and drug delivery system carriers. The solidification performed at lower temperature significantly improves storage stability of proteins, peptides, antibiotics, vaccines, and liposomes, which ar...

journal_title：Advances in experimental medicine and biology

authors： Izutsu KI

更新日期：2018-01-01 00:00:00

abstract：:Cyanobacteria are attractive hosts for converting carbon dioxide and sunlight into desirable chemical products. To engineer these organisms and manipulate their metabolic pathways, the biotechnology community has developed genetic tools to control gene expression. Many native cyanobacterial promoters and related seque...

journal_title：Advances in experimental medicine and biology

authors： Gordon GC,Pfleger BF

更新日期：2018-01-01 00:00:00

abstract：:Bryophytes are small land plants that have many morphological and physiological features different from vascular plants. With distinct water relations of bryophytes, many bryophyte species exhibit high degrees of tolerance to freezing and desiccation. The tolerance is sustained by the constitutive repair mechanism and...

journal_title：Advances in experimental medicine and biology

authors： Takezawa D

更新日期：2018-01-01 00:00:00

abstract：:Cyanobacteria are autotrophic prokaryotes that can perform oxygenic photosynthesis. The conversion of light and carbon dioxide into green fuels and chemicals has drawn considerable interest, and several dozen products have been successfully synthesized in genetically engineered cyanobacteria. However, during cultivati...

journal_title：Advances in experimental medicine and biology

authors： Xie Y,Chen L,Sun T,Zhang Y,Li T,Song X,Zhang W

更新日期：2018-01-01 00:00:00

abstract：:Biochemical imbalances, provoked by aging or a secondary illness, might directly affect the brain, causing severe problems, such as loss of memory or alteration of behavior patterns. Brain disorders are usually classified as injuries (such as stroke, hematomas, and concussions), tumors, and neurodegenerative (such as ...

journal_title：Advances in experimental medicine and biology

authors： Sussulini A,Hauser-Davis RA

更新日期：2018-01-01 00:00:00

abstract：:Animal models are an important tool to study the pathophysiology of Machado-Joseph Disease (MJD). So far, animal models using simple organisms (like the round worm Caenorhabditis elegans or the fruit fly drosophila) but also mammalian models (mouse and even a non-human primate model) have been generated to study MJD. ...

journal_title：Advances in experimental medicine and biology

authors： Schmidt J,Schmidt T

更新日期：2018-01-01 00:00:00

abstract：:Cardiovascular complications are a significant problem in systemically treated cancer patients. One such complication is Takotsubo cardiomyopathy, also known as Takotsubo syndrome. It is most frequently defined as a sudden and transient left or right ventricular systolic dysfunction; mimicking acute coronary syndrome,...

journal_title：Advances in experimental medicine and biology

authors： Budnik M,Kucharz J,Wiechno P,Demkow T,Kochanowski J,Górska E,Opolski G

更新日期：2018-01-01 00:00:00

abstract：:Spinal and Bulbar Muscular Atrophy (SBMA) is an inherited neuromuscular disorder caused by a CAG-polyglutamine (polyQ) repeat expansion in the androgen receptor (AR) gene. Unlike other polyQ diseases, where the function of the native causative protein is unknown, the biology of AR is well understood, and this knowledg...

journal_title：Advances in experimental medicine and biology

authors： Cortes CJ,La Spada AR

更新日期：2018-01-01 00:00:00

abstract：:Benign acute childhood myositis (BACM) is a syndrome classically occurring in children during the convalescent phase from a febrile upper respiratory tract infection, most commonly after influenza B. BACM can cause difficulty walking due to severe calf pain. Laboratory results show increased serum creatinine kinase an...

journal_title：Advances in experimental medicine and biology

authors： Szenborn L,Toczek-Kubicka K,Zaryczański J,Marchewka-Kowalik M,Miśkiewicz K,Kuchar E

更新日期：2018-01-01 00:00:00

abstract：:Drug resistance is a serious impediment to the treatment of cancer. The use of anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapies in patients with metastatic colorectal cancer is guided by the presence of activating point mutations in KRAS and NRAS genes in the primary tumour. However, RAS wild...

journal_title：Advances in experimental medicine and biology

authors： Pereira DM,Rodrigues CMP

更新日期：2018-01-01 00:00:00

abstract：:The CRISPR/Cas9 system has emerged as a powerful tool to edit the genome. Among many applications, the system generates the exciting possibility of engineering small and large portions of chromosomes to induce a variety of structural alterations such as deletions, inversions, insertions and inter-chromosomal transloca...

journal_title：Advances in experimental medicine and biology

authors： Cheong TC,Blasco RB,Chiarle R

更新日期：2018-01-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is an increasingly important cause of chronic liver disease globally. Similar to metabolic syndrome and obesity, NAFLD is associated with alternations in the gut microbiota and its related biological pathways. While the exact pathophysiology of NAFLD remains largely unknown, c...

journal_title：Advances in experimental medicine and biology

authors： Lau LHS,Wong SH

更新日期：2018-01-01 00:00:00

abstract：:The influenza Sentinel surveillance system is a source of valuable data about the dynamics of epidemic seasons in Poland. During the epidemic season 2016/2017, more than 1,000 samples were examined, of which 48% were positive for influenza diagnosis. The predominance of influenza A/H3N2/ was confirmed. Influenza B vir...

journal_title：Advances in experimental medicine and biology

authors： Cieślak K,Szymański K,Kowalczyk D,Hallmann-Szelińska E,Brydak LB

更新日期：2018-01-01 00:00:00

abstract：:Epigenetic memories are acquired information included in the chromatin or DNA such as methylation and histone modifications. Recent studies suggest that epigenetic memories determine the types of differentiated cells in each tissue. Moreover, the development of metabolic diseases induced by environmental factors durin...

journal_title：Advances in experimental medicine and biology

authors： Mochizuki K,Hariya N,Kubota T

更新日期：2018-01-01 00:00:00

abstract：:Alzheimer's disease, a type of dementia, affects memory, behavior, and cognitive processes in affected individuals. It is one of the prominent diseases, accounting for 60-80% of dementia cases and affecting a significant population of persons over the age of 65 years. While rare, Alzheimer's disease (AD) may affect th...

journal_title：Advances in experimental medicine and biology

authors： Cockerill I,Oliver JA,Xu H,Fu BM,Zhu D

更新日期：2018-01-01 00:00:00

abstract：:Vascular endothelial cells (ECs) and smooth muscle cells (VSMCs) are constantly exposed to hemodynamic forces in vivo, including flow shear stress and cyclic stretch caused by the blood flow. Numerous researches revealed that during various cardiovascular diseases such as atherosclerosis, hypertension, and vein graft,...

journal_title：Advances in experimental medicine and biology

authors： Qi YX,Han Y,Jiang ZL

更新日期：2018-01-01 00:00:00

abstract：:Aluminum industry has been producing more than a century of history. Aluminum is a light metal which is widely used in industrial applications. Occupational aluminum workers are an important source for high exposure Al population. With the world's demand for aluminum and the increasing production, between 2007 and 201...

journal_title：Advances in experimental medicine and biology

authors： Lu X

更新日期：2018-01-01 00:00:00

abstract：:Although pericytes have long been known for their roles in blood vessel regulation, it was not until a decade ago that their tissue regeneration potential began to be considered, after studies showed that pericytes were the in vivo counterparts of mesenchymal stem/stromal cells (MSCs). The prospective isolation and cu...

journal_title：Advances in experimental medicine and biology

authors： Esteves CL,Donadeu FX

更新日期：2018-01-01 00:00:00

abstract：:Clostridium difficile infection (CDI) is one of the most common healthcare-associated infections in the world and is a leading cause of morbidity and mortality in hospitalized patients.Although several antibiotics effectively treat CDI, some individuals do not respond to these drugs and may be cured by transplanting s...

journal_title：Advances in experimental medicine and biology

authors： Maida M,Mcilroy J,Ianiro G,Cammarota G

更新日期：2018-01-01 00:00:00

abstract：:Clostridium difficile infection (CDI) remains a considerable challenge to health care systems worldwide. Although CDI represents a significant burden on healthcare systems in Europe, few studies have attempted to estimate the consumption of resources associated with CDI in Europe. The reported extra costs attributable...

journal_title：Advances in experimental medicine and biology

authors： Reigadas Ramírez E,Bouza ES

更新日期：2018-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are pluripotent stem cells with the ability to differentiate into a variety of other connective tissue cells, such as chondral, bony, muscular, and tendon tissue. Bone marrow-derived MSCs are pluripotent cells that can differentiate among others into osteoblasts, adipocytes and chondrocyt...

journal_title：Advances in experimental medicine and biology

authors： Pintus E,Baldassarri M,Perazzo L,Natali S,Ghinelli D,Buda R

更新日期：2018-01-01 00:00:00

abstract：:In the modern era of next-generation genomics and Fourth Industrial Revolution, there is a growing demand for translational research that brings about not only impactful research but also potential commercialisation of R- and D-based products. Advancement of metabolic engineering and synthetic biology has put forward ...

journal_title：Advances in experimental medicine and biology

authors： Ramzi AB

更新日期：2018-01-01 00:00:00

abstract：:To develop an osteochondral tissue regeneration strategy it is extremely important to take into account the multiscale organization of the natural extracellular matrix. The structure and gradients of organic and inorganic components present in the cartilage and bone tissues must be considered together. Another critica...

journal_title：Advances in experimental medicine and biology

authors： Martins A,Reis RL,Neves NM

更新日期：2018-01-01 00:00:00

abstract：:Over the last few decades, Drosophila cancer models have made great contributions to our understanding toward fundamental cancer processes. Particularly, the development of genetic mosaic technique in Drosophila has enabled us to recapitulate basic aspects of human cancers, including clonal evolution, tumor microenvir...

journal_title：Advances in experimental medicine and biology

authors： Enomoto M,Siow C,Igaki T

更新日期：2018-01-01 00:00:00

abstract：:The Primo Vascular System (PVS) is new to most scientists despite that it was discovered in the 1960s by Bonghan Kim. Out of the many physiological functions reported, one of the most important PVS functions appears to be its role in the regeneration via a small (~1 μm) subcellular body called 'sanal.' According to Ki...

journal_title：Advances in experimental medicine and biology

authors： Kang KA,Pustovyy O,Globa L,Sorokulova I,Vodyanoy V

更新日期：2018-01-01 00:00:00

abstract：:Recent advances in regenerative medicine and cell-based therapy are bringing promising perspectives for the use of stem cells in clinical trials. Stem cells are undifferentiated cells capable of multilineage differentiation and available in numerous sources in the human body. Dental pulp constitutes an attractive sour...

journal_title：Advances in experimental medicine and biology

authors： Mortada I,Mortada R,Al Bazzal M

更新日期：2018-01-01 00:00:00

abstract：:Tracking of tissue oxygenation around chronic foot wounds may help direct therapy decisions in patients with peripheral artery disease (PAD). Novel sensing technology to enable such monitoring was tested over 9 months in a Sinclair mini-pig model. No adverse events were observed over the entire study period. Systemic ...

journal_title：Advances in experimental medicine and biology

authors： Nichols SP,Balaconis MK,Gant RM,Au-Yeung KY,Wisniewski NA

更新日期：2018-01-01 00:00:00

abstract：:Malignant epithelial tumors of the upper digestive tract are a major cause of cancer-related death worldwide. The most common of these cancers are head and neck squamous cell carcinomas (HNSCC) and esophageal cancers (EC), which are both characterized by early dissemination and poor prognosis. Although patients with e...

journal_title：Advances in experimental medicine and biology

authors： Sproll C,Fluegen G,Stoecklein NH

更新日期：2018-01-01 00:00:00

abstract：:Impaired oxygen utilization in skeletal muscle potentially contributes to muscle weakness in patients with malignant hematopoietic disease and may explain altered hemodynamic responses to exercise in these patients. We investigated whether changes in hemoglobin parameters in the tibialis anterior muscle in patients wi...

journal_title：Advances in experimental medicine and biology

authors： Wakasugi T,Morishita S,Kaida K,Itani Y,Kodama N,Ikegame K,Ogawa H,Domen K

更新日期：2018-01-01 00:00:00

abstract：:Medicine will experience many changes in the coming years because the so-called "medicine of the future" will be increasingly proactive, featuring four basic elements: predictive, personalized, preventive, and participatory. Drivers for these changes include the digitization of data in medicine and the availability of...

journal_title：Advances in experimental medicine and biology

authors： Alonso-Betanzos A,Bolón-Canedo V

更新日期：2018-01-01 00:00:00

abstract：:Sepsis is an exaggerated immune reaction to an infection, which leads to organ dysfunction especially circulatory failure. This is based on cellular processes, which are regulated by post-transcriptional gene expression modulations including microRNAs (miRNAs). In order to elucidate the role miRNAs play in septic proc...

journal_title：Advances in experimental medicine and biology

authors： Schmidt B,Roessler C,Schumann J

更新日期：2018-01-01 00:00:00

abstract：:Sex differences in cardiovascular diseases can be classified as those which are specific to one sex and those that differ in incidence, prevalence, etiology, symptomatology, response to treatment, morbidity, and mortality in one sex compared to the other. All sex differences in cardiovascular conditions have their bas...

journal_title：Advances in experimental medicine and biology

authors： Shufelt CL,Pacheco C,Tweet MS,Miller VM

更新日期：2018-01-01 00:00:00

abstract：:Oxygenation of a tumor is one of the most important predictive factors: hypoxia is associated with aggressive tumors and substantially lower survival rate. Despite this high relevance of tumor oxygenation, there is currently no bedside technique available to measure it in clinical routine care. The aim of this work is...

journal_title：Advances in experimental medicine and biology

authors： Kalyanov A,Germanier C,Ahnen L,Jiang J,Lindner S,Di Costanzo Mata A,Sánchez Majos S,Rudin M,Wolf M

更新日期：2018-01-01 00:00:00

abstract：:Cardiovascular disease remains the leading cause of morbidity and mortality for both women and men. Emerging evidence supports that ischemic heart disease (IHD) may manifest differently in women and men, in ways ranging from the clinical presentation, diagnosis, and management of disease to the basic biology and biome...

journal_title：Advances in experimental medicine and biology

authors： Taqueti VR

更新日期：2018-01-01 00:00:00

abstract：:Fat layer thickness (FLT) affects near infrared spectroscopy (NIRS) measurement. The aim of this study was to determine an indicator of muscle function with less influence of FLT, even without normalization, by comparing muscle O2 dynamics during exercise in subjects with similar physical characteristics except for FL...

journal_title：Advances in experimental medicine and biology

authors： Endo T,Kime R,Fuse S,Watanabe T,Murase N,Kurosawa Y,Hamaoka T

更新日期：2018-01-01 00:00:00

abstract：:When enough females and males are enrolled in clinical trials, much more relevant information is available on potential sex differences in device safety and effectiveness. Unfortunately, females have largely been underrepresented in clinical studies of cardiac medical device therapies for heart failure. In this chapte...

journal_title：Advances in experimental medicine and biology

authors： Zusterzeel R

更新日期：2018-01-01 00:00:00

abstract：:Cerebral infarction (CI) caused by middle cerebral artery occlusion exhibits a very high mortality rate. To reduce this rate, a decompressive hemicraniectomy (DHC) is performed clinically based on several randomized trials. In ischemic stroke, a state of malnutrition leads to poor outcomes. However, little evidence is...

journal_title：Advances in experimental medicine and biology

authors： Kutsuna N,Makita K,Goto K,Hirayama K,Kido G,Kagawa Y

更新日期：2018-01-01 00:00:00